About the Company
GTx, Inc. is a pharmaceutical company that is working on drugs in the selective estrogen receptor modulator (SERM) and selective androgen receptor modulator (SARM) classes. Its drugs in development include enobosarm (ostarine) and GTx-758. The company was founded in Memphis in 1997 by Mitch Steiner and Marc S. Hanover. The company was originally called Genotherapeutics, changed its name to GTx, Inc. in 2001, and reincorporated in Delaware in 2003. The company licensed toremifene from Orion Corporation, and licensed andarine, enobosarm and prostarine from the University of Tennessee Research Foundation; the SARM compounds from Tennessee had been invented by Karen Veverka and Michael Whitt and each later joined the company. The company held its IPO in February 2004. In 2006 GTx signed a partnership with Ipsen to develop toremifene, a selective estrogen receptor modulator to prevent prostate cancer and to prevent bone loss in men with prostate cancer; the FDA rejected the application to market the drug for this use in 2009, and Ipsen terminated the arrangement in 2011. In 2012 GTx sold its rights to toremifene to ProStrakan, a subsidiary of Kyowa Hakko Kirin, for around $19 million, and terminated its agreement with Orion. By 2007 enobosarm was in a Phase II trial, and that year Gtx signed an exclusive license agreement for its SARM program with Merck; Merck bought $30M in GtX stock, paid an upfront fee of $40M, and agreed to fund $15M in research over the next three years. The agreement also included royalties on any product brought to market and around $400M in biodollars. The companies ended the deal in 2010. In August 2013 GTx announced that enobosarm had failed in two Phase III clinical trials to treat wasting in people with lung cancer. In October 2013 the company laid off around 60% of its 88-person workforce, and Steiner resigned 6 months later. The company had invested around $35 million in the development of the drug. The company said at that time that is planned to pursue approval of enobosarm in Europe; the company was also still developing GTx-758 for castration-resistant prostate cancer. In 2016 GTx began Phase II trials, to see if enosobarm might be effective to treat stress urinary incontinence in women. In June 2019, GTx combined with Oncternal Therapeutics in a reverse merger. The combined company will operate under the name Oncternal Therapeutics, Inc.
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ONCT Oncternal Therapeutics, Inc.
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Oncternal Therapeutics Stock (NASDAQ:ONCT), Analyst Ratings, Price Targets, Predictions
$8.90-21.35% HC Wainwright & Co.
Oppenheimer Reaffirms Their Hold Rating on Oncternal Therapeutics (ONCT)
Oncternal Therapeutics (ONCT) Company Description: Oncternal Therapeutics, Inc. is a clinical-stage oncology company, which develops a diverse pipeline of treatments for cancers with critically unmet ...
Buy Rating Affirmed for Oncternal Therapeutics with Adjusted Price Target Amid Positive Financials and Upcoming Catalysts
Analyst Ram Selvaraju from H.C. Wainwright reiterated a Buy rating on Oncternal Therapeutics (ONCT – Research Report) and decreased the ...
Oncternal therapeutics director buys $27.7k of company stock
SAN DIEGO, CA – Oncternal Therapeutics, Inc. (NASDAQ:ONCT), a biopharmaceutical company specializing in the development of cancer therapies, reported a notable insider transaction. Robert James ...
Oncternal therapeutics director buys $58.6k in company stock
Oncternal Therapeutics, Inc. (NASDAQ:ONCT) director Robert James Wills has made a significant purchase of the company's common stock, according to a recent SEC filing. The transaction, which took ...
Oncternal therapeutics director buys $27.7k of company stock
SAN DIEGO, CA – Oncternal Therapeutics, Inc. (NASDAQ:ONCT), a biopharmaceutical company specializing in the development of cancer therapies, reported a notable insider transaction. Robert James Wills, ...
Oncternal Therapeutics Inc ONCT
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Oncternal Therapeutics Inc.
The Price to Earnings (P/E) ratio, a key valuation measure, is calculated by dividing the stock's most recent closing price by the sum of the diluted earnings per share from continuing operations ...
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