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Stock comparison · Signal date 2026-11-04

ALKS vs SYRE: stock comparison and AI forecast

Alkermes Plc. (ALKS) and Spyre Therapeutics, Inc. (SYRE) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

ALKS Alkermes Plc.

Market Cap
$7.67B
P/E Ratio
44.4x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

SYRE Spyre Therapeutics, Inc.

Market Cap
$8.42B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

ALKS · SYRE

Key facts

  • ALKS and SYRE have similar market capitalizations ($7.67B and $8.42B).
  • ALKS carries 1.38 times debt per unit of equity, against 0.07 times for SYRE.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricALKSSYRE
Market Cap$7.67B$8.42B
P/E Ratio44.36x–
P/B Ratio4.11x7.65x
EPS$1.03$-2.33
Book Value/Share$11.12$12.49
Revenue/Share$10.45–
FCF/Share$1.36–

Profitability & Margins

MetricALKSSYRE
ROE-0.0%-16.2%
ROA-0.0%-15.2%
ROIC1.7%-18.1%
Gross Margin82.9%–
Operating Margin3.7%–
Net Margin-0.0%–
EBT Margin0.7%–
Tax Rate103.1%0.0%

Financial Health

MetricALKSSYRE
Current Ratio2.42x18.53x
Quick Ratio2.02x–
D/E Ratio1.38x0.07x
Financial Leverage2.38x1.07x
Interest Coverage14.7x–
Working Capital$929M$1.11B

Cash Flow

MetricALKSSYRE
Operating Cash Flow$243M-$209M
Free Cash Flow$227M–
Capital Spending-$16M–
OCF Growth YoY-55.1%–
FCF Growth YoY-53.7%–
FCF/Sales13.0%–
CapEx/Sales0.9%–

Operational Efficiency

MetricALKSSYRE
Asset Turnover0.40x–
Receivables Turnover3.8x–
Inventory Turnover1.1x–
Fixed Assets Turnover8.2x–
Days Sales Outstanding96 days–
Days Inventory318 days–
Payables Period131 days–
Cash Conversion Cycle282 days–

Income Statement

MetricALKSSYRE
Total Revenue$1.75B–
Operating Income$64M-$201M
Net Income-$350K-$179M
R&D Expense$430M$216M
SG&A Expense$878M–
Cost of Goods Sold$300M–

Dividend & Shareholder Information

MetricALKSSYRE
Shares Outstanding168M88M
Net Income Growth-100.1%–
EPS Growth-51.2%–
FAQ

ALKS vs SYRE: stock comparison and AI forecast

Which is bigger, ALKS or SYRE?

ALKS and SYRE have similar market capitalizations ($7.67B and $8.42B).

Which one does Intratio's AI model rank higher, ALKS or SYRE?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.