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Stock comparison · Signal date 2026-11-03

ARWR vs SYRE: stock comparison and AI forecast

Arrowhead Pharmaceuticals, Inc. (ARWR) and Spyre Therapeutics, Inc. (SYRE) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

ARWR Arrowhead Pharmaceuticals, Inc.

Market Cap
$8.54B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

SYRE Spyre Therapeutics, Inc.

Price
$95.51 +38.2% · 6M
Market Cap
$8.42B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

ARWR · SYRE

Key facts

  • ARWR and SYRE have similar market capitalizations ($8.54B and $8.42B).
  • ARWR carries 3.54 times debt per unit of equity, against 0.07 times for SYRE.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricARWRSYRE
Market Cap$8.54B$8.42B
P/B Ratio18.35x7.65x
EPS$-1.47$-2.33
Book Value/Share$3.30$12.49
Revenue/Share$6.63–
FCF/Share$-0.53–

Profitability & Margins

MetricARWRSYRE
ROE–-16.2%
ROA–-15.2%
ROIC-12.4%-18.1%
Operating Margin-24.2%–
EBT Margin-26.9%–
Tax Rate-8.0%0.0%

Financial Health

MetricARWRSYRE
Current Ratio5.90x18.53x
D/E Ratio3.54x0.07x
Financial Leverage4.54x1.07x
Interest Coverage-2321.4x–
Working Capital$1.39B$1.11B

Cash Flow

MetricARWRSYRE
Operating Cash Flow-$59M-$209M
Free Cash Flow-$75M–
Capital Spending-$16M–
OCF Growth YoY-370.3%–
FCF/Sales-8.0%–
CapEx/Sales1.7%–

Operational Efficiency

MetricARWRSYRE
Asset Turnover0.44x–
Receivables Turnover109.4x–
Fixed Assets Turnover2.5x–
Days Sales Outstanding3 days–

Income Statement

MetricARWRSYRE
Total Revenue$936M–
Operating Income-$226M-$201M
Net Income–-$179M
R&D Expense$723M$216M

Dividend & Shareholder Information

MetricARWRSYRE
Shares Outstanding141M88M
FAQ

ARWR vs SYRE: stock comparison and AI forecast

Which is bigger, ARWR or SYRE?

ARWR and SYRE have similar market capitalizations ($8.54B and $8.42B).

Which one does Intratio's AI model rank higher, ARWR or SYRE?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.