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Stock comparison · Signal date 2026-11-03

AXSM vs IONS: stock comparison and AI forecast

Axsome Therapeutics, Inc. (AXSM) and Ionis Pharmaceuticals Inc (IONS) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

AXSM Axsome Therapeutics, Inc.

Price
$136.01 -39.2% · 6M
Market Cap
$7.12B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

IONS Ionis Pharmaceuticals Inc

Market Cap
$7.23B
P/E Ratio
–
Size
mid-cap
AI Forecast
NO CURRENT FORECAST
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

AXSM · IONS

Key facts

  • AXSM and IONS have similar market capitalizations ($7.12B and $7.23B).
  • AXSM turns -18.2% of its revenue into net income, against -213.0% for IONS.
  • AXSM carries 6.84 times debt per unit of equity, against 5.81 times for IONS.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricAXSMIONS
Market Cap$7.12B$7.23B
P/B Ratio67.57x16.45x
EPS$-3.05$-3.77
Book Value/Share$2.01$2.65
Revenue/Share$16.52$1.60
FCF/Share$-1.58$-3.37

Profitability & Margins

MetricAXSMIONS
ROE-149.2%-128.5%
ROA-19.0%-18.9%
ROIC-47.6%-22.2%
Gross Margin93.2%94.0%
Operating Margin-17.4%-224.0%
Net Margin-18.2%-213.0%
EBT Margin-18.1%-211.8%
Tax Rate-0.4%-0.6%

Financial Health

MetricAXSMIONS
Current Ratio1.42x7.89x
Quick Ratio1.34x7.73x
D/E Ratio6.84x5.81x
Financial Leverage7.84x6.81x
Interest Coverage3.2x-22.1x
Working Capital$215M$2.18B

Cash Flow

MetricAXSMIONS
Operating Cash Flow-$82M-$496M
Free Cash Flow-$83M-$561M
Capital Spending-$840K-$64M
FCF/Sales-9.6%-211.4%
CapEx/Sales0.1%24.3%

Operational Efficiency

MetricAXSMIONS
Asset Turnover1.05x0.09x
Receivables Turnover2.5x–
Inventory Turnover1.4x0.3x
Fixed Assets Turnover917.6x1.7x
Days Sales Outstanding145 days–
Days Inventory266 days1158 days
Payables Period600 days1087 days
Cash Conversion Cycle-189 days–

Income Statement

MetricAXSMIONS
Total Revenue$865M$265M
Operating Income-$151M-$594M
Net Income-$157M-$565M
R&D Expense$198M–
SG&A Expense$766M$528M
Cost of Goods Sold$58M$16M

Dividend & Shareholder Information

MetricAXSMIONS
Shares Outstanding52M166M
FAQ

AXSM vs IONS: stock comparison and AI forecast

Which is bigger, AXSM or IONS?

AXSM and IONS have similar market capitalizations ($7.12B and $7.23B).

Which one does Intratio's AI model rank higher, AXSM or IONS?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.