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Stock comparison · Signal date 2026-11-10

KNSA vs SYRE: stock comparison and AI forecast

Kiniksa Pharmaceuticals International, Plc (KNSA) and Spyre Therapeutics, Inc. (SYRE) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

KNSA Kiniksa Pharmaceuticals International, Plc

Price
$98.76 +69.2% · 6M
Market Cap
$7.76B
P/E Ratio
91.5x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

SYRE Spyre Therapeutics, Inc.

Market Cap
$9.16B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

KNSA · SYRE

Key facts

  • SYRE is 1.2 times larger than KNSA by market capitalization ($9.16B against $7.76B).
  • KNSA carries 0.38 times debt per unit of equity, against 0.05 times for SYRE.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricKNSASYRE
Market Cap$7.76B$9.16B
P/E Ratio91.45x–
P/B Ratio10.93x8.71x
EPS$1.08$-2.19
Book Value/Share$9.04$11.93
Revenue/Share$12.04–
FCF/Share$2.51–

Profitability & Margins

MetricKNSASYRE
ROE15.4%-25.1%
ROA11.1%-24.0%
ROIC16.5%-23.6%
Gross Margin90.2%–
Operating Margin13.8%–
Net Margin11.6%–
EBT Margin15.4%–
Tax Rate25.0%0.0%

Financial Health

MetricKNSASYRE
Current Ratio3.91x27.40x
Quick Ratio3.35x–
D/E Ratio0.38x0.05x
Financial Leverage1.38x1.05x
Working Capital$558M$1.06B

Cash Flow

MetricKNSASYRE
Operating Cash Flow$199M-$249M
Free Cash Flow$197M–
Capital Spending-$2M–
OCF Growth YoY93.3%–
FCF Growth YoY93.8%–
FCF/Sales20.9%–
CapEx/Sales0.2%–

Operational Efficiency

MetricKNSASYRE
Asset Turnover0.96x–
Receivables Turnover30.7x–
Inventory Turnover0.9x–
Fixed Assets Turnover383.9x–
Days Sales Outstanding12 days–
Days Inventory424 days–
Payables Period16 days–
Cash Conversion Cycle419 days–

Income Statement

MetricKNSASYRE
Total Revenue$946M–
Operating Income$130M-$250M
Net Income$110M-$264M
R&D Expense$136M$260M
SG&A Expense$247M–
Cost of Goods Sold$93M–

Dividend & Shareholder Information

MetricKNSASYRE
Shares Outstanding79M88M
Net Income Growth205.1%–
FAQ

KNSA vs SYRE: stock comparison and AI forecast

Which is bigger, KNSA or SYRE?

SYRE is 1.2 times larger than KNSA by market capitalization ($9.16B against $7.76B).

Which one does Intratio's AI model rank higher, KNSA or SYRE?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.