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Stock comparison · Signal date 2026-11-04

KRYS vs TWST: stock comparison and AI forecast

Krystal Biotech, Inc. (KRYS) and Twist Bioscience Corp (TWST) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Biological Products, (No Diagnostic Substances)

KRYS Krystal Biotech, Inc.

Price
$295.90 +3.1% · 6M
Market Cap
$9.04B
P/E Ratio
41.5x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Biological Products, (No Diagnostic Substances)

TWST Twist Bioscience Corp

Price
$129.04 +129.6% · 6M
Market Cap
$8.80B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-04 → 2026-11-03

Six-month price performance

Closing prices rebased to 100 at the start of the window.

140210280350
KRYS +3.1% TWST +129.6%
KRYS · TWST

Key facts

  • KRYS and TWST have similar market capitalizations ($9.04B and $8.80B).
  • Over the last six months TWST returned +129.6% and KRYS +3.1%.
  • KRYS turns 47.9% of its revenue into net income, against -31.7% for TWST.
  • TWST carries 0.51 times debt per unit of equity, against 0.10 times for KRYS.
  • Both companies share the SEC industry classification Biological Products, (No Diagnostic Substances).
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricKRYSTWST
Market Cap$9.04B$8.80B
P/E Ratio41.45x–
P/B Ratio6.30x19.74x
EPS$7.36$-2.24
Book Value/Share$48.44$7.11
Revenue/Share$15.86$6.89
FCF/Share$10.46$-1.49

Profitability & Margins

MetricKRYSTWST
ROE15.7%-30.7%
ROA14.2%-20.3%
ROIC15.8%-26.3%
Gross Margin–52.0%
Operating Margin48.4%-33.6%
Net Margin47.9%-31.7%
EBT Margin55.1%-31.5%
Tax Rate13.0%-0.6%

Financial Health

MetricKRYSTWST
Current Ratio7.89x2.67x
Quick Ratio7.53x2.38x
D/E Ratio0.10x0.51x
Financial Leverage1.10x1.51x
Interest Coverage–-2274.8x
Working Capital$980M$201M

Cash Flow

MetricKRYSTWST
Operating Cash Flow$324M-$53M
Free Cash Flow$310M-$93M
Capital Spending-$14M-$40M
OCF Growth YoY83.8%–
FCF Growth YoY87.3%–
FCF/Sales66.0%-21.6%
CapEx/Sales3.0%9.3%

Operational Efficiency

MetricKRYSTWST
Asset Turnover0.30x0.64x
Receivables Turnover3.5x6.6x
Inventory Turnover–5.9x
Fixed Assets Turnover3.1x3.9x
Days Sales Outstanding103 days55 days
Days Inventory–62 days
Payables Period–30 days
Cash Conversion Cycle–87 days

Income Statement

MetricKRYSTWST
Total Revenue$470M$432M
Operating Income$228M-$145M
Net Income$225M-$137M
R&D Expense$60M$72M
SG&A Expense$156M$290M
Cost of Goods Sold–$207M

Dividend & Shareholder Information

MetricKRYSTWST
Shares Outstanding30M63M
Net Income Growth13.2%–
EPS Growth1.7%–
FAQ

KRYS vs TWST: stock comparison and AI forecast

Which is bigger, KRYS or TWST?

KRYS and TWST have similar market capitalizations ($9.04B and $8.80B).

Which stock performed better over the last six months, KRYS or TWST?

Over the last six months TWST returned +129.6% and KRYS +3.1%.

Which one does Intratio's AI model rank higher, KRYS or TWST?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.