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Stock comparison · Signal date 2026-11-03

MDGL vs PTGX: stock comparison and AI forecast

Madrigal Pharmaceuticals, Inc. (MDGL) and Protagonist Therapeutics, Inc (PTGX) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

MDGL Madrigal Pharmaceuticals, Inc.

Price
$431.15 -16.9% · 6M
Market Cap
$9.96B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

PTGX Protagonist Therapeutics, Inc

Price
$139.37 +40.0% · 6M
Market Cap
$9.02B
P/E Ratio
176.4x
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-04 → 2026-11-03

Six-month price performance

Closing prices rebased to 100 at the start of the window.

80100120140160
MDGL -16.9% PTGX +40.0%
MDGL · PTGX

Key facts

  • MDGL is 1.1 times larger than PTGX by market capitalization ($9.96B against $9.02B).
  • Over the last six months PTGX returned +40.0% and MDGL -16.9%.
  • MDGL carries 1.38 times debt per unit of equity, against 0.05 times for PTGX.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricMDGLPTGX
Market Cap$9.96B$9.02B
P/E Ratio–176.41x
P/B Ratio19.02x10.72x
EPS$-12.87$0.79
Book Value/Share$22.67$13.01
Revenue/Share$61.51$3.49
FCF/Share$-8.93$2.02

Profitability & Margins

MetricMDGLPTGX
ROE-62.1%–
ROA-26.1%–
ROIC-37.1%6.9%
Operating Margin-22.7%25.9%
Net Margin-22.9%–
EBT Margin-21.9%36.4%
Tax Rate–1.7%

Financial Health

MetricMDGLPTGX
Current Ratio3.20x21.71x
Quick Ratio2.94x–
D/E Ratio1.38x0.05x
Financial Leverage2.38x1.05x
Interest Coverage-24.1x–
Working Capital$825M$770M

Cash Flow

MetricMDGLPTGX
Operating Cash Flow-$198M$131M
Free Cash Flow-$206M$131M
Capital Spending-$9M-$610K
OCF Growth YoY–231.8%
FCF Growth YoY–252.0%
FCF/Sales-14.5%57.9%
CapEx/Sales0.6%0.3%

Operational Efficiency

MetricMDGLPTGX
Asset Turnover1.14x0.25x
Receivables Turnover7.4x–
Fixed Assets Turnover122.6x65.3x
Days Sales Outstanding49 days–

Income Statement

MetricMDGLPTGX
Total Revenue$1.42B$226M
Operating Income-$323M$58M
Net Income-$325M–
R&D Expense$490M$175M
SG&A Expense$1.01B–

Dividend & Shareholder Information

MetricMDGLPTGX
Shares Outstanding23M65M
EPS Growth–-14.1%
FAQ

MDGL vs PTGX: stock comparison and AI forecast

Which is bigger, MDGL or PTGX?

MDGL is 1.1 times larger than PTGX by market capitalization ($9.96B against $9.02B).

Which stock performed better over the last six months, MDGL or PTGX?

Over the last six months PTGX returned +40.0% and MDGL -16.9%.

Which one does Intratio's AI model rank higher, MDGL or PTGX?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.