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Stock comparison · Signal date 2026-11-03

PFE vs VRTX: stock comparison and AI forecast

Pfizer Inc (PFE) and Vertex Pharmaceuticals Inc / Ma (VRTX) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
NYSE · Pharmaceutical Preparations

PFE Pfizer Inc

Market Cap
$174.81B
P/E Ratio
37.9x
Size
large-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

VRTX Vertex Pharmaceuticals Inc / Ma

Market Cap
$136.87B
P/E Ratio
31.5x
Size
large-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

PFE · VRTX

Key facts

  • PFE is 1.3 times larger than VRTX by market capitalization ($174.81B against $136.87B).
  • VRTX trades at 31.4 times trailing earnings, PFE at 37.9 times.
  • VRTX turns 35.0% of its revenue into net income, against 6.8% for PFE.
  • PFE carries 1.36 times debt per unit of equity, against 0.35 times for VRTX.
  • PFE yields 5.60% in dividends; VRTX pays none.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricPFEVRTX
Market Cap$174.81B$136.87B
P/E Ratio37.86x31.45x
P/B Ratio2.05x6.76x
Dividend Yield5.60%–
EPS$0.81$17.17
Book Value/Share$14.95$79.89
Revenue/Share$11.18$49.66
FCF/Share$1.93$14.98

Profitability & Margins

MetricPFEVRTX
ROE5.1%21.8%
ROA2.1%16.1%
ROIC–20.3%
Gross Margin73.2%86.0%
Operating Margin–38.0%
Net Margin6.8%35.0%
EBT Margin6.6%41.9%
Tax Rate-3.9%16.5%

Financial Health

MetricPFEVRTX
Current Ratio1.27x3.19x
Quick Ratio0.96x2.74x
D/E Ratio1.36x0.35x
Financial Leverage2.36x1.35x
Interest Coverage–402.2x
Working Capital$8.71B$8.61B

Cash Flow

MetricPFEVRTX
Operating Cash Flow$13.40B$4.29B
Free Cash Flow$10.98B$3.80B
Capital Spending-$2.42B-$497M
OCF Growth YoY-11.8%11.6%
FCF Growth YoY-11.7%8.5%
FCF/Sales17.2%30.2%
CapEx/Sales3.8%4.0%

Operational Efficiency

MetricPFEVRTX
Asset Turnover0.32x0.46x
Receivables Turnover5.1x5.9x
Inventory Turnover1.7x1.0x
Fixed Assets Turnover3.4x7.6x
Days Sales Outstanding72 days62 days
Days Inventory212 days365 days
Payables Period98 days89 days
Cash Conversion Cycle186 days338 days

Income Statement

MetricPFEVRTX
Total Revenue$63.70B$12.59B
Operating Income–$4.78B
Net Income$4.33B$4.41B
R&D Expense$11.05B$3.91B
SG&A Expense$13.72B$2.01B
Cost of Goods Sold$17.08B$1.76B

Dividend & Shareholder Information

MetricPFEVRTX
Dividends Per Share$1.72–
Payout Ratio212.3%–
Shares Outstanding5700M253M
Net Income Growth-59.7%21.1%
EPS Growth-57.6%21.7%
FAQ

PFE vs VRTX: stock comparison and AI forecast

Which is bigger, PFE or VRTX?

PFE is 1.3 times larger than VRTX by market capitalization ($174.81B against $136.87B).

Which is cheaper on earnings, PFE or VRTX?

VRTX trades at 31.4 times trailing earnings, PFE at 37.9 times.

Which one does Intratio's AI model rank higher, PFE or VRTX?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.