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Stock comparison · Signal date 2026-11-10

PTGX vs RYTM: stock comparison and AI forecast

Protagonist Therapeutics, Inc (PTGX) and Rhythm Pharmaceuticals, Inc. (RYTM) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

PTGX Protagonist Therapeutics, Inc

Price
$135.90 +31.3% · 6M
Market Cap
$8.79B
P/E Ratio
34.6x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

RYTM Rhythm Pharmaceuticals, Inc.

Price
$113.94 +30.4% · 6M
Market Cap
$7.85B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-11 → 2026-11-10

Six-month price performance

Closing prices rebased to 100 at the start of the window.

90105120135150
PTGX +31.3% RYTM +30.4%
PTGX · RYTM

Key facts

  • PTGX is 1.1 times larger than RYTM by market capitalization ($8.79B against $7.85B).
  • Over the last six months PTGX returned +31.3% and RYTM +30.4%.
  • PTGX turns 155.8% of its revenue into net income, against -69.0% for RYTM.
  • RYTM carries 2.75 times debt per unit of equity, against 0.06 times for PTGX.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricPTGXRYTM
Market Cap$8.79B$7.85B
P/E Ratio34.58x–
P/B Ratio8.11x89.18x
EPS$3.93$-2.88
Book Value/Share$16.77$1.28
Revenue/Share$3.39$4.08
FCF/Share$1.69–

Profitability & Margins

MetricPTGXRYTM
ROE31.6%-220.3%
ROA29.9%-43.7%
ROIC29.6%-64.1%
Gross Margin–88.2%
Operating Margin147.1%-66.7%
Net Margin155.8%-69.0%
EBT Margin158.4%-68.5%
Tax Rate2.3%-0.8%

Financial Health

MetricPTGXRYTM
Current Ratio19.85x2.78x
Quick Ratio–2.57x
D/E Ratio0.06x2.75x
Financial Leverage1.06x5.04x
Interest Coverage–-29.4x
Working Capital$1.05B$268M

Cash Flow

MetricPTGXRYTM
Operating Cash Flow$110M-$82M
Free Cash Flow$109M–
Capital Spending-$760K–
OCF Growth YoY67.9%–
FCF Growth YoY71.3%–
FCF/Sales49.7%–
CapEx/Sales0.3%–

Operational Efficiency

MetricPTGXRYTM
Asset Turnover0.19x0.63x
Receivables Turnover–7.2x
Inventory Turnover–1.1x
Fixed Assets Turnover66.1x493.4x
Days Sales Outstanding–51 days
Days Inventory–344 days
Payables Period–118 days
Cash Conversion Cycle–277 days

Income Statement

MetricPTGXRYTM
Total Revenue$220M$281M
Operating Income$323M-$187M
Net Income$342M-$194M
R&D Expense$176M$180M
SG&A Expense–$255M
Cost of Goods Sold–$33M

Dividend & Shareholder Information

MetricPTGXRYTM
Shares Outstanding65M69M
Net Income Growth645.5%–
EPS Growth182.7%–
FAQ

PTGX vs RYTM: stock comparison and AI forecast

Which is bigger, PTGX or RYTM?

PTGX is 1.1 times larger than RYTM by market capitalization ($8.79B against $7.85B).

Which stock performed better over the last six months, PTGX or RYTM?

Over the last six months PTGX returned +31.3% and RYTM +30.4%.

Which one does Intratio's AI model rank higher, PTGX or RYTM?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.