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Stock comparison · Signal date 2026-11-11

EWTX vs IONS: stock comparison and AI forecast

Edgewise Therapeutics, Inc. (EWTX) and Ionis Pharmaceuticals Inc (IONS) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

EWTX Edgewise Therapeutics, Inc.

Price
$46.53 +36.8% · 6M
Market Cap
$5.05B
P/E Ratio
5.5x
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

IONS Ionis Pharmaceuticals Inc

Price
$31.00 -58.9% · 6M
Market Cap
$5.15B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-12 → 2026-11-10

Six-month price performance

Closing prices rebased to 100 at the start of the window.

5075100125
EWTX +36.8% IONS -58.9%
EWTX · IONS

Key facts

  • EWTX and IONS have similar market capitalizations ($5.05B and $5.15B).
  • Over the last six months EWTX returned +36.8% and IONS -58.9%.
  • IONS carries 6.40 times debt per unit of equity, against 0.09 times for EWTX.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricEWTXIONS
Market Cap$5.05B$5.15B
P/E Ratio5.53x–
P/B Ratio3.10x13.09x
EPS$8.41$-2.93
Book Value/Share$15.03$2.37
Revenue/Share–$2.11
FCF/Share$-1.86$-3.71

Profitability & Margins

MetricEWTXIONS
ROE61.8%-138.8%
ROA56.7%-18.8%
ROIC-13.3%-22.8%
Gross Margin–95.2%
Operating Margin–-160.8%
Net Margin–-155.6%
EBT Margin–-154.8%
Tax Rate–-0.5%

Financial Health

MetricEWTXIONS
Current Ratio12.30x5.43x
Quick Ratio–5.36x
D/E Ratio0.09x6.40x
Financial Leverage1.09x7.40x
Interest Coverage–-28.2x
Working Capital$1.63B$1.93B

Cash Flow

MetricEWTXIONS
Operating Cash Flow-$202M-$544M
Free Cash Flow-$202M-$616M
Capital Spending-$380K-$72M
FCF/Sales–-175.4%
CapEx/Sales–20.4%

Operational Efficiency

MetricEWTXIONS
Asset Turnover–0.12x
Inventory Turnover–0.6x
Fixed Assets Turnover–2.2x
Days Inventory–614 days
Payables Period–582 days

Income Statement

MetricEWTXIONS
Total Revenue–$351M
Operating Income-$218M-$565M
Net Income$1.01B-$547M
R&D Expense$165M–
SG&A Expense–$585M
Cost of Goods Sold–$17M

Dividend & Shareholder Information

MetricEWTXIONS
Shares Outstanding109M166M
FAQ

EWTX vs IONS: stock comparison and AI forecast

Which is bigger, EWTX or IONS?

EWTX and IONS have similar market capitalizations ($5.05B and $5.15B).

Which stock performed better over the last six months, EWTX or IONS?

Over the last six months EWTX returned +36.8% and IONS -58.9%.

Which one does Intratio's AI model rank higher, EWTX or IONS?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.