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Stock comparison · Signal date 2026-11-06

IONS vs ORKA: stock comparison and AI forecast

Ionis Pharmaceuticals Inc (IONS) and Oruka Therapeutics, Inc. (ORKA) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

IONS Ionis Pharmaceuticals Inc

Price
$38.80 -49.0% · 6M
Market Cap
$6.45B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

ORKA Oruka Therapeutics, Inc.

Market Cap
$6.36B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

IONS · ORKA

Key facts

  • IONS and ORKA have similar market capitalizations ($6.45B and $6.36B).
  • IONS carries 5.81 times debt per unit of equity, against 0.02 times for ORKA.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricIONSORKA
Market Cap$6.45B$6.36B
P/B Ratio14.66x5.70x
EPS$-3.77$-4.15
Book Value/Share$2.65$16.83
Revenue/Share$1.60–
FCF/Share$-3.37$-1.53

Profitability & Margins

MetricIONSORKA
ROE-128.5%–
ROA-18.9%–
ROIC-22.2%-13.9%
Gross Margin94.0%–
Operating Margin-224.0%–
Net Margin-213.0%–
EBT Margin-211.8%–
Tax Rate-0.6%–

Financial Health

MetricIONSORKA
Current Ratio7.89x38.51x
Quick Ratio7.73x–
D/E Ratio5.81x0.02x
Financial Leverage6.81x1.02x
Interest Coverage-22.1x-15.9x
Working Capital$2.18B$862M

Cash Flow

MetricIONSORKA
Operating Cash Flow-$496M-$101M
Free Cash Flow-$561M-$101M
Capital Spending-$64M-$230K
FCF/Sales-211.4%–
CapEx/Sales24.3%–

Operational Efficiency

MetricIONSORKA
Asset Turnover0.09x–
Inventory Turnover0.3x–
Fixed Assets Turnover1.7x–
Days Inventory1158 days–
Payables Period1087 days–

Income Statement

MetricIONSORKA
Total Revenue$265M–
Operating Income-$594M-$155M
Net Income-$565M–
R&D Expense–$129M
SG&A Expense$528M–
Cost of Goods Sold$16M–

Dividend & Shareholder Information

MetricIONSORKA
Shares Outstanding166M66M
FAQ

IONS vs ORKA: stock comparison and AI forecast

Which is bigger, IONS or ORKA?

IONS and ORKA have similar market capitalizations ($6.45B and $6.36B).

Which one does Intratio's AI model rank higher, IONS or ORKA?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.