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Stock comparison · Signal date 2026-11-05

SEPN vs TRVI: stock comparison and AI forecast

Septerna, Inc. (SEPN) and Trevi Therapeutics, Inc. (TRVI) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

SEPN Septerna, Inc.

Price
$47.88 +93.8% · 6M
Market Cap
$2.23B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

TRVI Trevi Therapeutics, Inc.

Price
$13.86 -5.5% · 6M
Market Cap
$1.99B
P/E Ratio
–
Size
small-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-06 → 2026-11-04

Six-month price performance

Closing prices rebased to 100 at the start of the window.

90120150180
SEPN +93.8% TRVI -5.5%
SEPN · TRVI

Key facts

  • SEPN is 1.1 times larger than TRVI by market capitalization ($2.23B against $1.99B).
  • Over the last six months SEPN returned +93.8% and TRVI -5.5%.
  • SEPN carries 0.47 times debt per unit of equity, against 0.03 times for TRVI.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricSEPNTRVI
Market Cap$2.23B$1.99B
P/B Ratio5.78x6.20x
EPS$-0.83$-0.34
Book Value/Share$8.29$2.26
Revenue/Share$2.12–
FCF/Share$2.25$-0.37

Profitability & Margins

MetricSEPNTRVI
ROE-6.3%-15.9%
ROA-4.3%-15.5%
ROIC-8.9%-18.5%
Operating Margin-44.0%–
Net Margin-24.5%–
EBT Margin-23.2%–
Tax Rate-5.8%0.1%

Financial Health

MetricSEPNTRVI
Current Ratio4.99x37.28x
D/E Ratio0.47x0.03x
Financial Leverage1.47x1.03x
Interest Coverage–-6121.0x
Working Capital$317M$317M

Cash Flow

MetricSEPNTRVI
Operating Cash Flow$106M-$53M
Free Cash Flow$105M-$53M
Capital Spending-$910K-$240K
FCF/Sales106.3%–
CapEx/Sales0.9%–

Operational Efficiency

MetricSEPNTRVI
Asset Turnover0.17x–
Receivables Turnover8.1x–
Fixed Assets Turnover25.4x–
Days Sales Outstanding45 days–

Income Statement

MetricSEPNTRVI
Total Revenue$99M–
Operating Income-$44M-$60M
Net Income-$24M-$51M
R&D Expense$121M$41M

Dividend & Shareholder Information

MetricSEPNTRVI
Shares Outstanding47M142M
FAQ

SEPN vs TRVI: stock comparison and AI forecast

Which is bigger, SEPN or TRVI?

SEPN is 1.1 times larger than TRVI by market capitalization ($2.23B against $1.99B).

Which stock performed better over the last six months, SEPN or TRVI?

Over the last six months SEPN returned +93.8% and TRVI -5.5%.

Which one does Intratio's AI model rank higher, SEPN or TRVI?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.