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Stock comparison · Signal date 2026-11-05

PVLA vs SEPN: stock comparison and AI forecast

Palvella Therapeutics, Inc. (PVLA) and Septerna, Inc. (SEPN) compared on price performance, valuation, profitability and the daily AI forecast. · Alpha · vs market

Share
Nasdaq · Pharmaceutical Preparations

PVLA Palvella Therapeutics, Inc.

Price
$152.93 +18.1% · 6M
Market Cap
$2.34B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Nasdaq · Pharmaceutical Preparations

SEPN Septerna, Inc.

Price
$47.88 +93.8% · 6M
Market Cap
$2.23B
P/E Ratio
–
Size
mid-cap
AI Forecast
Full analysis →
Model output

Which one does the AI model favor?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

6M · 2026-05-06 → 2026-11-04

Six-month price performance

Closing prices rebased to 100 at the start of the window.

90120150180
PVLA +18.1% SEPN +93.8%
PVLA · SEPN

Key facts

  • PVLA and SEPN have similar market capitalizations ($2.34B and $2.23B).
  • Over the last six months SEPN returned +93.8% and PVLA +18.1%.
  • SEPN carries 0.47 times debt per unit of equity, against 0.17 times for PVLA.
  • Both companies share the SEC industry classification Pharmaceutical Preparations.
Fundamentals

Fundamentals side by side

Trailing twelve months.

Valuation & Market

MetricPVLASEPN
Market Cap$2.34B$2.23B
P/B Ratio10.79x5.78x
EPS$-5.57$-0.83
Book Value/Share$15.04$8.29
Revenue/Share–$2.12
FCF/Share–$2.25

Profitability & Margins

MetricPVLASEPN
ROE-28.4%-6.3%
ROA-24.3%-4.3%
ROIC-23.9%-8.9%
Operating Margin–-44.0%
Net Margin–-24.5%
EBT Margin–-23.2%
Tax Rate0.0%-5.8%

Financial Health

MetricPVLASEPN
Current Ratio21.18x4.99x
D/E Ratio0.17x0.47x
Financial Leverage1.17x1.47x
Interest Coverage-24.0x–
Working Capital$241M$317M

Cash Flow

MetricPVLASEPN
Operating Cash Flow-$37M$106M
Free Cash Flow–$105M
Capital Spending–-$910K
FCF/Sales–106.3%
CapEx/Sales–0.9%

Operational Efficiency

MetricPVLASEPN
Asset Turnover–0.17x
Receivables Turnover–8.1x
Fixed Assets Turnover–25.4x
Days Sales Outstanding–45 days

Income Statement

MetricPVLASEPN
Total Revenue–$99M
Operating Income-$58M-$44M
Net Income-$62M-$24M
R&D Expense$35M$121M

Dividend & Shareholder Information

MetricPVLASEPN
Shares Outstanding14M47M
FAQ

PVLA vs SEPN: stock comparison and AI forecast

Which is bigger, PVLA or SEPN?

PVLA and SEPN have similar market capitalizations ($2.34B and $2.23B).

Which stock performed better over the last six months, PVLA or SEPN?

Over the last six months SEPN returned +93.8% and PVLA +18.1%.

Which one does Intratio's AI model rank higher, PVLA or SEPN?

Intratio's model scores both stocks every trading day. Sign in to see their current direction; the exact ratings and forecasts come with a plan or a free follow slot.

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This analysis is generated automatically using our proprietary AI systems and should not be considered personalized investment advice. Past performance does not guarantee future results. Always conduct your own research and consider consulting a financial advisor before making investment decisions.